期刊
WORLD JOURNAL OF CLINICAL ONCOLOGY
卷 5, 期 3, 页码 412-424出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.5306/wjco.v5.i3.412
关键词
Breast cancer; Tumor biology; Subtypes; Predictive factors; Prognostic factors
类别
Breast cancer is a heterogeneous complex of diseases, a spectrum of many subtypes with distinct biological features that lead to differences in response patterns to various treatment modalities and clinical outcomes. Traditional classification systems regarding biological characteristics may have limitations for patient-tailored treatment strategies. Tumors with similar clinical and pathological presentations may have different behaviors. Analyses of breast cancer with new molecular techniques now hold promise for the development of more accurate tests for the prediction of recurrence. Gene signatures have been developed as predictors of response to therapy and protein gene products that have direct roles in driving the biology and clinical behavior of cancer cells are potential targets for the development of novel therapeutics. The present review summarizes current knowledge in breast cancer molecular biology, focusing on novel prognostic and predictive factors. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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