期刊
JOURNAL OF CRANIOFACIAL SURGERY
卷 29, 期 7, 页码 1880-1883出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SCS.0000000000004747
关键词
Bioresorbable scaffold; cleft alveolus reconstruction; human bone marrow cells; three-dimensional printing
类别
资金
- Priority Research Centers Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2017R1A6A1A03015562]
Bone tissue engineering technology based on scaffold has been applied for cleft lip and palate treatment. However, clinical applications of patient-specific three-dimensional (3D) scaffolds have rarely been performed. In this study, a clinical case using patient-specific 3D-printed bioresorbable scaffold with bone marrow stromal cells collected from iliac crest in the operating room has been introduced. At 6-month after transplantation, the bone volume of the newly regenerated bone was approximately 45% of the total defect volume. Bone mineral density of the newly regenerated bone was about 75% compared to the surrounding bone. The Hounsfield unit value was higher than that of cancellous maxillary alveolar bone and lower than that of the cortical maxillary alveolar bone. Bone-marrow-derived mesenchymal stem cells-seeded 3D-printed patient-specific polycaprolactone scaffolds offer a promising alternative for alveolar cleft reconstruction and other bony defects.
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