期刊
JOURNAL OF CONTROLLED RELEASE
卷 284, 期 -, 页码 144-151出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2018.06.020
关键词
Iontophoresis; Chemotherapies; Devices; Drug delivery; Cancer
资金
- UNC Medical Scientists Training Program [NIGMS-2-T32-GM008719]
- PhRMA Foundation
Despite major advancements in cancer treatments, there are still many limitations to therapy including off-target effects, drug resistance, and control of cancer-related symptoms. There are opportunities for local drug delivery devices to intervene at various stages of cancer to provide curative and palliative benefit. Iontophoretic devices that deliver drugs locally to a region of interest have been adapted for the treatment of cancer. These devices have shown promise in pre-clinical and clinical studies for retinoblastoma, skin, bladder, and pancreatic cancers. Herein, we review iontophoretic devices used in the management of cancer.
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