期刊
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
卷 55, 期 6, 页码 3572-3577出版社
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.14-13912
关键词
cone dystrophy; cone-rod dystrophy; fundus autofluorescence
资金
- Japan Ministry of Health, Labor and Welfare [12103069]
PURPOSE. To evaluate the clinical utility of wide-field fundus autofluorescence (FAF) in patients with cone dystrophy and cone-rod dystrophy. METHODS. Sixteen patients with cone dystrophy (CD) and 41 patients with cone-rod dystrophy (CRD) were recruited at one institution. The right eye of each patient was included for analysis. We obtained wide-field FAF images using a ultra-widefield retinal imaging device and measured the area of abnormal FAF. The association between the area of abnormal FAF and the results of visual acuity measurements, kinetic perimetry, and electroretinography (ERG) were investigated. RESULTS. The mean age of the participants was 51.4 +/- 17.4 years, and the mean logarithm of the minimum angle of resolution was 1.00 +/- 0.57. The area of abnormal FAF correlated with the scotoma measured by the Goldman perimetry I/4e isopter (rho = 0.79, P < 0.001). The area also correlated with amplitudes of the rod ERG (rho = -0.63, P < 0.001), combined ERG a-wave (rho = -0.72, P < 0.001), combined ERG b-wave (rho = -0.66, P < 0.001), cone ERG (rho = -0.44, P = 0.001), and flicker ERG (rho = -0.47, P < 0.001). CONCLUSIONS. The extent of abnormal FAF reflects the severity of functional impairment in patients with cone-dominant retinal dystrophies. Fundus autofluorescence measurements are useful for predicting retinal function in these patients.
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