期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 526, 期 7, 页码 1110-1130出版社
WILEY
DOI: 10.1002/cne.24396
关键词
motor cortex; primates; pyramidal tracts; recovery of function; spinal cord injuries; transcriptome; RRID: AB_514497; RRID: AB_10013482; RRID: AB_2313606; RRID: AB_2149209
资金
- Core Research for Evolutionary Science and Technology (CREST)
- Precursory Research for Embryonic Science and Technology (PRESTO) of Japan Science and Technology Agency (JST)
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [24300196, 15H01819]
- Grants-in-Aid for Scientific Research [15K16365] Funding Source: KAKEN
The present study aimed to assess the molecular bases of cortical compensatory mechanisms following spinal cord injury in primates. To accomplish this, comprehensive changes in gene expression were investigated in the bilateral primary motor cortex (M1), dorsal premotor cortex (PMd), and ventral premotor cortex (PMv) after a unilateral lesion of the lateral corticospinal tract (l-CST). At 2 weeks after the lesion, a large number of genes exhibited altered expression levels in the contralesional M1, which is directly linked to the lesioned l-CST. Gene ontology and network analyses indicated that these changes in gene expression are involved in the atrophy and plasticity changes observed in neurons. Orchestrated gene expression changes were present when behavioral recovery was attained 3 months after the lesion, particularly among the bilateral premotor areas, and a large number of these genes are involved in plasticity. Moreover, several genes abundantly expressed in M1 of intact monkeys were upregulated in both the PMd and PMv after the l-CST lesion. These area-specific and time-dependent changes in gene expression may underlie the molecular mechanisms of functional recovery following a lesion of the l-CST.
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