期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 510, 期 -, 页码 292-301出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2017.09.085
关键词
Nanocomposites; Photothermal conversion; Photothermal therapy; Dual-modal imaging
资金
- National Natural Science Foundation of P.R. China (NSFC) [51072026, 51573023]
- Development of Science and Technology Plan Projects of Jilin Province [20130206002GX, 20170101185JC]
Multifunctional nanocomposites (NCs) incorporating magnetic, luminescent and photothermal conversion properties are endowed with potential application in many fields such as imaging, tumor detection, drug delivery and therapy. Here, multifunctional MWCNTs-NaGdF4:Yb3+, Er3+, Eu3+ NCs, which offer the potential for integrated bioimaging and photothermal therapy (PTT) were fabricated by a facile hydrothermal method. The resulting sample exhibits uniform morphology, bright dual-modal luminescence and intrinsic paramagnetic properties. Under near-infrared laser excitation, NCs have excellent photothermal conversion properties. In addition, the MTT assay in HeLa cells shows that the NCs have good biocompatibility. Moreover, the up-conversion luminescence (UCL) imaging, X-ray computed tomography (CT) imaging and PTT in vitro of NCs were investigated. The results indicate that NCs can be used for dual-modal imaging-guided diagnose and PTT of cancer cells. (C) 2017 Elsevier Inc. All rights reserved.
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