期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 530, 期 -, 页码 547-555出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2018.07.001
关键词
Photothermal therapy; Computed tomography imaging; Theranostic agent; Polypyrrole nanocomposites
资金
- National Natural Science Foundation of China [21176102, 21176215, 21476136, 21171035, 51472049, 8152010831]
- Science and Technology Commission of Shanghai Municipality [15430501200]
- Sino-German Center for Research Promotion [GZ935]
- Innovation Program of Shanghai Municipal Education Commission [14ZZ160]
- Guidance Fund of Shanghai Committee of Science and Technology [15411968800]
- Connotation Construction Project of SUES [Nhky-2015-05]
Multifunctional nanocomposites for image-guided cancer therapy are highly desired in clinical application. Herein, a novel theranostic agent based on gold and ferroferric oxide nanoparticles coating polypyrrole particles (PPy@Fe3O4/Au nanocomposites) for computed tomography (CT) and magnetic resonance (MR) imaging guided photothermal therapy was successfully assembled by a very facile electrostatic adsorption method. PPy@Fe3O4/Au nanocomposites exhibit good biocompatibility in vitro and in vivo. Because of high r(2) relaxivity of Fe3O4 and high X-ray attenuation ability of Au, the PPy@Fe3O4/Au nanocomposites exhibited desirable CT and MR imaging performance, which provide more comprehensive and accurate diagnostic information. Moreover, PPy@Fe3O4/Au nanocomposites can efficiently kill cancer cells by hyperthermia with the guiding of CT and MR imaging, even completely ablate tumours. Hence, the electrostatic adsorption assembled PPy@Fe3O4/Au nanocomposites have great potential in clinical application for diagnosing and treating tumour in the future. (C) 2018 Elsevier Inc. All rights reserved.
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