期刊
NATURE REVIEWS IMMUNOLOGY
卷 14, 期 9, 页码 631-639出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3726
关键词
-
类别
资金
- US National Institutes of Health [R37 AI034206]
- Ludwig Center at Memorial Sloan-Kettering Cancer Center (MSKCC), New York, USA
Innate lymphocytes - including natural killer cells and the recently discovered innate lymphoid cells - have crucial roles during infection, tissue injury and inflammation. Innate signals regulate the activation and homeostasis of innate lymphocytes. The contribution of the adaptive immune system to the coordination of innate lymphocyte responses is less well understood. In this Opinion article, we review our current understanding of the interactions between adaptive and innate lymphocytes, and propose a model in which T cells of the adaptive immune system function as antigen-specific sensors for the activation of innate lymphocytes to amplify and instruct local immune responses. We highlight the potential roles of regulatory and helper T cells in these processes, and discuss major questions in the emerging area of crosstalk between adaptive and innate lymphocytes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据