期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 56, 期 8, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01728-17
关键词
Orientia; Rickettsia; diagnostics; rickettsioses; scrub typhus; spotted fever; vector-borne diseases
类别
Rickettsioses are globally distributed and caused by the family Rickettsiaceae, which comprise a diverse and expanding list of organisms. These include two genera, Rickettsia and Orientia. Serology has been traditionally the mainstay of diagnosis, although this has been limited by cross-reactions among closely related members and diminished sensitivity/utility in the acute phase of illness. Other techniques, such as nucleic acid amplification tests using blood specimens or tissue swabs/biopsy specimens, sequencing, and mass spectrometry, have emerged in recent years for both pathogen and vector identification. This paper provides a concise review of the rickettsioses and the traditional and newer technologies available for their diagnosis.
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