期刊
CURRENT CARDIOVASCULAR IMAGING REPORTS
卷 7, 期 9, 页码 -出版社
SPRINGER
DOI: 10.1007/s12410-014-9287-8
关键词
T1 mapping; Extracellular space; Heart failure; Extracellular volume fraction; Diffuse fibrosis; Intracellular space; Cardiac remodelling; Myocardial intracellular volume; Myocytes; Interstitium
资金
- British Heart Foundation [FS/10/40/28260, FS/12/56/29723] Funding Source: Medline
- Department of Health [DRF-2013-06-102] Funding Source: Medline
Heart failure (HF) is a major and growing cause of morbidity and mortality. Despite initial successes, there have been few recent therapeutic advances. A better understanding of HF pathophysiology is needed with renewed focus on the myocardium itself. A new imaging technique is now available that holds promise. T1 mapping is a cardiovascular magnetic resonance (CMR) technique for non-invasive myocardial tissue characterization. T1 alters with disease. Pre-contrast (native) T1 changes with a number of processes such as fibrosis, edema and infiltrations. If a post contrast scan is also done, the extracellular volume fraction (ECV) can be measured, a direct measure of the interstitium and its reciprocal, the cell volume. This dichotomy is fundamental - and now measurable promising more targeted therapy and new insights into disease biology.
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