期刊
BIOMEDICAL ENGINEERING LETTERS
卷 4, 期 3, 页码 213-222出版社
SPRINGERNATURE
DOI: 10.1007/s13534-014-0153-z
关键词
Photoacoustic tomography; Acoustic-resolution photoacoustic microscopy; Preclinical imaging
资金
- NIPA IT Consilience Creative Program [NIPA-2013-H0203-13-1001]
- NRF Engineering Research Center [NRF-2011-0030075]
- NRF Pioneer Research Center Program [NRF-2014M3C1A3017229]
- NRF China-ROK Joint Research Project of the Ministry of Science, ICT and Future Planning, Republic of Korea [NRF-2013K1A3A1A20046921]
- National Research Foundation of Korea [2012-0009541] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Even if conventional optical imaging systems such as multi-photon microscopy (MPM), confocal microscopy (CM), fluorescence microscopy (FM), and optical coherence tomography (OCT) are regarded as revolutionary microscopic imaging modalities to reveal the inner information of biological tissues with very high spatial resolution, it is inherently restricted to image deep tissues due to strong optical scatting in biological tissues. Photoacoustic imaging (PAI) is a hybrid imaging modality to combine strong optical contrast and high ultrasonic resolution in deep tissues. In a microscopic imaging perspective, photoaocustic microscopy (PAM) can be implemented in two forms: optical-resolution (OR) and acoustic-resolution (AR) PAM. In OR-PAM, the lateral spatial resolution is determined by tight optical focusing, but the penetration depth is limited to one optical transport mean free path. In AR-PAM, the lateral spatial resolution is determined by loose acoustic focusing, but the penetration depth can be much enhanced and reach to several centimeters. Therefore, AR-PAM gains great attention for both preclinical and clinical applications. This review explains the principle, implementation, and applications of AR-PAM.
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