期刊
NATURE REVIEWS CANCER
卷 14, 期 9, 页码 632-641出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3789
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资金
- V Foundation for Cancer Research, Susan G. Komen for the Cure
- American Cancer Society
- Center for Rare and Neglected Disease at the University of Notre Dame, Indiana, USA
- Advanced Diagnostics & Therapeutics Initiative at the University of Notre Dame
- Coleman Foundation
Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However, during tumour progression and metastasis, cancerous epithelial cells must adapt to and survive in the absence of ECM. During the past 20 years, several cellular changes, including anoikis, have been shown to regulate cell viability when cells become detached from the ECM. In this Opinion article, we review in detail how cancer cells can overcome or take advantage of these specific processes. Gaining a better understanding of how cancer cells survive during detachment from the ECM will be instrumental in designing chemotherapeutic strategies that aim to eliminate ECM-detached metastatic cells.
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