期刊
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
卷 1092, 期 -, 页码 122-130出版社
ELSEVIER
DOI: 10.1016/j.jchromb.2018.05.047
关键词
Metabolomics; H1N1; Flos Lonicerae Japonica; Fructus Forsythiae; GC-MS
资金
- Jiangsu Provincial 333 High-level Talents Cultivation Project [BRA2016427]
- Jiangsu Provincial Six Talent Peaks Project [YY-022]
Flos Lonicerae Japonica-Fructus Foisythiae herb pair (Yin-Qiao in Chinese, YQ), is used clinically for the treatment of viral pneumonia due to its heat-clearing and detoxifying functions. In the present work, the effect of YQ in H1N1-induced inflammation in mice was investigated by metabolomics based on GC-MS. Body weight and histological results were used to assess the lung injury, while the levels of IL-6 and TNF-alpha in plasma were used to evaluate the extent of inflammation. The acquired GC-MS data were further subjected to multivariate data analysis, and the significantly altered metabolites identified. After statistical and pathway analysis, 17 significantly altered metabolites and 3 possible metabolic pathways were found in plasma between normal and H1N1-induced pneumonia mice, while 17 significant differential metabolites were identified when YQ treatment group was compared with model group. This work indicates that oral administration of YQ could protect mice from H1N1-induced inflammation partially by ameliorating the associated metabolic disturbances.
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