期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 38, 期 7, 页码 1125-1148出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X18773871
关键词
MicroRNA mimics; microRNA inhibitors; stroke; traumatic brain injury; spinal cord injury
资金
- National Institutes of Health [NS091175, NS094930, NS086820, NS075035, NS079153, AG042292, NS101718, NS089901]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS101718, R01NS086820, R01NS079153, R21NS094930, R01NS106950, R01NS089901, R01NS091175, R01NS097000, R01NS075035] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG042292] Funding Source: NIH RePORTER
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and spinal cord injury (SCI), are important causes of death and long-term disability worldwide. MicroRNA (miRNA), small non-coding RNA molecules that negatively regulate gene expression, can serve as diagnostic biomarkers and are emerging as novel therapeutic targets for CNS injuries. MiRNA-based therapeutics include miRNA mimics and inhibitors (antagomiRs) to respectively decrease and increase the expression of target genes. In this review, we summarize current miRNA-based therapeutic applications in stroke, TBI and SCI. Administration methods, time windows and dosage for effective delivery of miRNA-based drugs into CNS are discussed. The underlying mechanisms of miRNA-based therapeutics are reviewed including oxidative stress, inflammation, apoptosis, blood-brain barrier protection, angiogenesis and neurogenesis. Pharmacological agents that protect against CNS injuries by targeting specific miRNAs are presented along with the challenges and therapeutic potential of miRNA-based therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据