期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 38, 期 8, 页码 1293-1298出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X18780130
关键词
Stroke; microbiota; germfree; T cells; microglia; neuroinflammation
资金
- Excellence cluster of the German research foundation Munich Cluster for Systems Neurology (SyNergy)''
Microbiome alterations have been shown to affect stroke outcome. However, to what extent the presence of a gut microbiome per se is affecting post-stroke neuroinflammation has not been tested. By comparing germfree mice with recolonized (Ex-GF) and conventional SPF mice, we were able to demonstrate that bacterial colonization reduces stroke volumes. Bacterial colonization increased cerebral expression of cytokines as well as microglia/macrophage cell counts in contrast to improved stroke outcome. Interestingly, the microbiome-mediated brain protection was absent in lymphocyte-deficient mice. These findings support the concept of lymphocyte-driven protective neuroinflammation after stroke under control of the microbiome.
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