期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 233, 期 8, 页码 5670-5683出版社
WILEY
DOI: 10.1002/jcp.26417
关键词
aging; cardiac; cardiac progenitor cells; fibroblast; fibrosis; Notch; regeneration
资金
- University of Genova
- Italian Ministry of Research and Education (MIUR)
- Giovani Ricercatori Rita Levi Montalcini
- Universita degli Studi di Ferrara
- Fondi per le necessita di base della ricerca
The knowledge of the cellular events occurring in the aging heart has dramatically expanded in the last decade and is expected to further grow in years to come. It is now clear that impaired function and loss of cardiomyocytes are major features of cardiac aging, but other events are likewise important. In particular, accumulating experimental evidence highlights the importance of fibroblast and cardiac progenitor cell (CPC) dysfunction. The Notch pathway regulates cardiomyocyte, fibroblast, and CPC activity and, thus, may be critically involved in heart disease associated with advanced age, especially heart failure. In a translational perspective, thorough investigation of the Notch system in the aging myocardium may lead to the identification of molecular targets for novel therapies for age-related cardiac disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据