期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 119, 期 5, 页码 4113-4119出版社
WILEY
DOI: 10.1002/jcb.26609
关键词
colorectal cancer; exosomes; microRNAs
资金
- National Natural Science Foundation of China [81601408, 31570941, 31270993]
- Natural Science Foundation of Shandong Province [ZR2016HQ12]
- Medical and Health Science and Technology Development Program of Shandong Province [2016WS0681, 2016WS0686]
- Weifang Science and Technology Development Program [2016YX016, 2017YX019]
Accumulating data have suggested exosome-delivered microRNAs (miRNAs) play critical role in carcinogenesis and cancer progression. However, little is known about the influence of exosomal miR-6803-5p on the development and prognosis of colorectal cancer (CRC). Levels of serum exosomal miR-6803-5p were determined by microarray analysis and verified by quantitative real-time PCR (qRT-PCR). Outcomes of overall survival (OS) and disease-free survival (DFS) of CRC patients were estimated by Kaplan-Meier analysis. We used cox regression analysis to investigate the association between exosomes-encapsulated miR-6803-5p and the clinicopathological factors of CRC patients. The exosomal miR-6803-5p was significantly increased in serum samples from patients with CRC in contrast to healthy controls. Significantly higher levels of serum exosomal miR-6803-5p were observed in CRC patients at later TNM stage or with lymph node metastasis as well as liver metastasis. Patients with elevated levels of serum exosomal miR-6803-5p had much poorer OS and DFS. Cox regression analysis revealed high levels of exosomal miR-6803-5p was associated with poor prognosis in CRC independent of other confounding factors. Thus, exosomal miR-6803-5p is a potential diagnostic and prognostic biomarker for patients with CRC.
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