期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 22, 期 9, 页码 4024-4033出版社
WILEY
DOI: 10.1111/jcmm.13692
关键词
exosomes; microRNA; osteogenic phenotype transition; vascular calcification
资金
- National Natural Science Foundation of China [81670676, 81422011, 81370837, 81600351, 81500563]
- Central Universities [2015ykzd09, 8100018823702]
- Natural Science Foundation of Guangdong Province [2014A030313035]
- Guangzhou Science and Technology Project [201607010075]
- Key Laboratory of Malignant Tumor Molecular Mechanism and Translational Medicine of Guangzhou Bureau of Science and Information Technology [[2013]163]
- Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes [KLB09001]
- Macao Science and Technology Development Fund [052/2013/A2]
Vascular calcification (VC) is caused by hydroxyapatite deposition in the intimal and medial layers of the vascular wall, leading to severe cardiovascular events in patients with hypertension, chronic kidney disease and diabetes mellitus. VC occurrences involve complicated mechanism networks, such as matrix vesicles or exosomes production, osteogenic differentiation, reduced cell viability, aging and so on. However, with present therapeutic methods targeting at VC ineffectively, novel targets for VC treatment are demanded. Exosomes are proven to participate in VC and function as initializers for mineral deposition. Secreted exosomes loaded with microRNAs are also demonstrated to modulate VC procession in recipient vascular smooth muscle cells. In this review, we targeted at the roles of exosomes during VC, especially at their effects on transporting biological information among cells. Moreover, we will discuss the potential mechanisms of exosomes in VC.
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