期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 22, 期 3, 页码 2001-2006出版社
WILEY
DOI: 10.1111/jcmm.13479
关键词
exosome; zeta potential; hypothesis; signalling; physical interaction
资金
- ISRAEL SCIENCE FOUNDATION [1315/14]
Exosomes are extracellular nanovesicles that mediate a number of cellular processes, including intracellular signalling. There are many published examples of exosome-exosome dimers; however, their relevance has not been explored. Here, we propose that cells release exosomes to physically interact with incoming exosomes, forming dimers that we hypothesize attenuate incoming exosome-mediated signalling. We discuss experiments to test this hypothesis and potential relevance in health and disease.
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