期刊
JOURNAL OF CELL SCIENCE
卷 131, 期 14, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.203653
关键词
Chromosome segregation; Comparative biology; Evolution; Mitosis; Nuclear envelope; Spindle
类别
资金
- Wellcome Trust [103741/Z/14/Z]
- Wellcome Trust [103741/Z/14/Z] Funding Source: Wellcome Trust
A long-appreciated variation in fundamental cell biological processes between different species is becoming increasingly tractable due to recent breakthroughs in whole-genome analyses and genome editing techniques. However, the bulk of our mechanistic understanding in cell biology continues to come from just a few well-established models. In this Review, I use the highly diverse strategies of chromosome segregation in eukaryotes as an instrument for a more general discussion on phenotypic variation, possible rules underlying its emergence and its utility in understanding conserved functional relationships underlying this process. Such a comparative approach, supported by modern molecular biology tools, might provide a wider, holistic view of biology that is difficult to achieve when concentrating on a single experimental system.
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