期刊
JOURNAL OF CELL SCIENCE
卷 131, 期 15, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.217091
关键词
Septin; Actin; Cdc42; Ethanol stress; Yeast; Multiple small cortical rings of septin
类别
资金
- Japan Society for the Promotion of Science [17H03795]
- Grants-in-Aid for Scientific Research [17H03795] Funding Source: KAKEN
Short-term exposure to severe ethanol stress has adverse effects on yeast cells. However, limited information is available on the effects of long-term exposure to severe ethanol stress. In this study, we examined the effects of a long-term treatment with a high ethanol concentration [10% (v/v)] on yeast morphology. We found that long-term severe ethanol stress induced the continuous depolarization of the actin cytoskeleton and hypertrophy in yeast cells, accompanied by the aberrant localization of septins, which formed multiple small cortical rings (MSCRs). The formation of MSCRs was also induced by the continuous depolarization of the actin cytoskeleton caused by a treatment with latrunculin-A, an effective inhibitor of actin polymerization. Unlike the formation of conventional septin rings, the formation of MSCRs did not require Cdc42 and its effectors, Gic1, Gic2 and Cla4. These results provide novel insights into the effects of persistent actin depolarization caused by long-term exposure to severe ethanol stress on yeast cytomorphology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据