期刊
CLINICAL PSYCHOLOGY REVIEW
卷 34, 期 5, 页码 417-427出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cpr.2014.06.003
关键词
Depression; Endophenotype; Neuroticism; Cortisol; Frontal asymmetry; Cognitive biases
资金
- NIMH NIH HHS [R01 MH069942] Funding Source: Medline
Endophenotypes are proposed to occupy an intermediate position in the pathway between genotype and phenotype in genetically complex disorders such as depression. To be considered an endophenotype, a construct must meet a set of criteria proposed by Gottesman and Gould (2003). In this qualitative review, we summarize evidence for each criterion for several putative endophenotypes for depression: neuroticism, morning cortisol, frontal asymmetry of cortical electrical activity, reward learning, and biases of attention and memory. Our review indicates that while there is strong support for some depression endophenotypes, other putative endophenotypes lack data or have inconsistent findings for core criteria. (C) 2014 Elsevier Ltd. All rights reserved.
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