期刊
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
卷 14, 期 -, 页码 S937-S941出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/0973-1482.193894
关键词
Breast cancer; gene expression; lymphatic metastasis; PTEN; SHIP
类别
资金
- National Nature Science Foundation [81473687]
- Natural Science Foundation of Shandong Province of China [ZR2009CM039, ZR2013HM038]
- Scientific research project in the Science and Technology Development Plan of Shandong province [2011HW084]
Lymph node metastasis is the most common form of metastasis in breast cancer and a crucial indicator influencing breast cancer treatment results. The biological process of lymph node metastasis involves deficiency and mutation of tumor suppressor genes. PTEN and SHIP are critical indicators used to detect occurrence, development, invasion, and metastasis of breast cancer. Loss of expressions of PTEN and SHIP may contribute to lymphatic metastasis of breast cancer, so they can be used as objective indicators for judging the biological behavior of breast cancer. In this study, we perform a comprehensive analysis to investigate the effect of PTEN and SHIP gene expression on regulating lymph node metastasis in breast cancer.
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