期刊
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
卷 58, 期 3, 页码 252-266出版社
WILEY
DOI: 10.1002/ajim.22419
关键词
flight crew; ionizing radiation; cosmic; circadian rhythm disruption; cohort studies
资金
- National Cancer Institute
- Office of Women's Health of the U.S. Department of Health and Human Services
BackgroundFlight attendants may have elevated breast cancer incidence (BCI). We evaluated BCI's association with cosmic radiation dose and circadian rhythm disruption among 6,093 female former U.S. flight attendants. MethodsWe collected questionnaire data on BCI and risk factors for breast cancer from 2002-2005. We conducted analyses to evaluate (i) BCI in the cohort compared to the U.S. population; and (ii) exposure-response relations. We applied an indirect adjustment to estimate whether parity and age at first birth (AFB) differences between the cohort and U.S. population could explain BCI that differed from expectation. ResultsBCI was elevated but may be explained by lower parity and older AFB in the cohort than among U.S. women. BCI was not associated with exposure metrics in the cohort overall. Significant positive associations with both were observed only among women with parity of three or more. ConclusionsFuture cohort analyses may be informative on the role of these occupational exposures and non-occupational risk factors. Am. J. Ind. Med. 58:252-266, 2015. (c) 2015 Wiley Periodicals, Inc.
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