期刊
RAMBAM MAIMONIDES MEDICAL JOURNAL
卷 5, 期 4, 页码 -出版社
RAMBAM HEALTH CARE CAMPUS
DOI: 10.5041/RMMJ.10158
关键词
Cancer vaccines; dendritic cells; hematological malignancies; immunotherapy
The recognition that the development of cancer is associated with acquired immunodeficiency, mostly against cancer cells themselves, and understanding pathways inducing this immunosuppression, has led to a tremendous development of new immunological approaches, both vaccines and drugs, which overcome this inhibition. Both passive (e.g. strategies relying on the administration of specific T cells) and active vaccines (e.g. peptide-directed or whole-cell vaccines) have become attractive immunological approaches, inducing cell death by targeting tumor-associated antigens. Whereas peptide-targeted vaccines are usually directed against a single antigen, whole-cell vaccines (e.g. dendritic cell vaccines) are aimed to induce robust responsiveness by targeting several tumor-related antigens simultaneously. The combination of vaccines with new immuno-stimulating agents which target immunosuppressive checkpoints (anti-CTLA4, PD-1, etc.) is likely to improve and maintain immune response induced by vaccination.
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