期刊
JOURNAL OF BIOPHOTONICS
卷 11, 期 10, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201700358
关键词
brain implant; neuroprosthesis; optoelectronics; optogenetics; optrode; prosthesis
资金
- Wellcome Trust [102037/Z/13/Z]
- Seventh Framework Programme [24986]
- Engineering and Physical Sciences Research Council [NS/A000026/1]
- Wellcome Trust
- European Commission
Implantable photonic probes are of increasing interest to the field of biophotonics and in particular, optogenetic neural stimulation. Active probes with onboard light emissive elements allow for electronic multiplexing and can be manufactured through existing microelectronics methods. However, as the optogenetics field moves towards clinical practice, an important question arises as to whether such probes will cause excessive thermal heating of the surrounding tissue. Light emitting diodes typically produce more heat than light. The resultant temperature rise of the probe surface therefore needs to be maintained under the regulatory limit of 2 degrees C. This work combines optical and thermal modelling, which have been experimental verified. Analysis has been performed on the effect of probe/emitter geometries, emitter, and radiance requirements. Finally, the effective illumination volume has been calculated within thermal limits for different probe emitter types and required thresholds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据