期刊
NATURE REVIEWS IMMUNOLOGY
卷 14, 期 10, 页码 667-685出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3738
关键词
-
类别
资金
- Swedish Medical Research Council
- Swedish National Health Service
- Danish Research Council
- Medical Research Council, UK
- Wellcome Trust
- Tenovus Scotland
The intestine represents the largest compartment of the immune system. It is continually exposed to antigens and imnnunomodulatory agents from the diet and the commensal microbiota, and it is the port of entry for many clinically important pathogens. Intestinal immune processes are also increasingly implicated in controlling disease development elsewhere in the body. In this Review, we detail the anatomical and physiological distinctions that are observed in the small and large intestines, and we suggest how these may account for the diversity in the immune apparatus that is seen throughout the intestine. We describe how the distribution of innate, adaptive and innate-like immune cells varies in different segments of the intestine and discuss the environmental factors that may influence this. Finally, we consider the implications of regional immune specialization for inflammatory disease in the intestine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据