期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 106, 期 8, 页码 2158-2170出版社
WILEY
DOI: 10.1002/jbm.a.36414
关键词
neurotrophin-3; controlled artificial release system; inflammation; nerve fiber regeneration; spinal cord injury
资金
- National Key R&D Program of China [2017YFA0104704]
- National Natural Science Foundation of China [81330028, U1301223]
- Science Foundation of Ministry of Education of China [201300193035]
- Science Foundation of Guangdong Province [2017B020210012]
- Co-innovation Science Foundation of Guangzhou City [201508020215, 201704020221]
Spinal cord injury (SCI) normally results in cell death, scarring, cavitation, inhibitory molecules release, etc., which are regarded as a huge obstacle to reconnect the injured neuronal circuits because of the lack of effective stimulus. In this study, a functional gelatin sponge scaffold was used to inhibit local inflammation, enhance nerve fiber regeneration, and improve neural conduction in the canine. This scaffold had good porosity and modified with neurotrophin-3 (NT-3)/fibroin complex, which showed sustained release in vitro. After the scaffold was transplanted into canine spinal cord hemisection model, hindlimb movement, and neural conduction were improved evidently. Migrating host cells, newly formed neurons with associated synaptic structures together with functional blood vessels with intact endothelium in the regenerating tissue were identified. Taken together, the results demonstrated that using bioactive scaffold could establish effective microenvironment stimuli for endogenous regeneration, providing a potential and practical strategy for treatment of spinal cord injury. (c) 2018 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2158-2170, 2018.
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