期刊
JOURNAL OF BIOMATERIALS APPLICATIONS
卷 32, 期 9, 页码 1212-1221出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328218754615
关键词
Alginate; film; Aloe vera; dressing; healing
A new alginate dressing with Aloe vera gel was developed and used to study its cutaneous healing effect in vivo by surgical wounds in Wistar rats. The aloe-alginate film was characterized by Fourier-transform infrared spectroscopy, mechanical properties, scanning electron microscopy, hydration rate, and calcium release. The aloe-alginate film demonstrated desirable physical and mechanical characteristics for wound dressing application. The animals were divided in three groups (n=20): gauze bandage, alginate film, and aloe-alginate film. The histological analysis on the 3rd, 7th, 14th, and 22nd days after the treatment showed that the aloe-alginate films modulated the inflammatory phase and decreased the quantity of macrophages when compared to the alginate film group and the control (gauze bandage). The evaluation of collagen fibers showed a decrease in type III and increase in type I fibers on group treated with aloe-alginate film suggesting an improvement in the progression of the healing process.
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