期刊
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
卷 23, 期 4, 页码 613-620出版社
SPRINGER
DOI: 10.1007/s00775-018-1541-0
关键词
Carbon monoxide dehydrogenase; Active site; Iron-sulfur cluster; Maturation
资金
- CNRS
- Aix Marseille Universite
- Agence Nationale de la Recherche [ANR-12-BS08-0014, ANR-14-CE05-0010, ANR-15-CE05-0020, ANR-17-CE11-0027]
- A*MIDEX Grant by the French Government Investissements d'Avenir program [ANR-11-IDEX-0001-02]
- Erasmus program
Nickel-containing enzymes are diverse in terms of function and active site structure. In many cases, the biosynthesis of the active site depends on accessory proteins which transport and insert the Ni ion. We review and discuss the literature related to the maturation of carbon monoxide dehydrogenases (CODH) which bear a nickel-containing active site consisting of a [Ni-4Fe-4S] center called the C-cluster. The maturation of this center has been much less studied than that of other nickel-containing enzymes such as urease and NiFe hydrogenase. Several proteins present in certain CODH operons, including the nickel-binding proteins CooT and CooJ, still have unclear functions. We question the conception that the maturation of all CODH depends on the accessory protein CooC described as essential for nickel insertion into the active site. The available literature reveals biological variations in CODH active site biosynthesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据