期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 293, 期 27, 页码 10524-10535出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.TM118.000372
关键词
genomic instability; DNA recombination; DNA repair; DNA topology; DNA damage; DNA endonuclease; DNA helicase; DNA polymerase; DNA topoisomerase
资金
- National Institutes of Health [GM58015, CA92276]
Homologous recombination enables the cell to access and copy intact DNA sequence information in trans, particularly to repair DNA damage affecting both strands of the double helix. Here, we discuss the DNA transactions and enzymatic activities required for this elegantly orchestrated process in the context of the repair of DNA double-strand breaks in somatic cells. This includes homology search, DNA strand invasion, repair DNA synthesis, and restoration of intact chromosomes. Aspects of DNA topology affecting individual steps are highlighted. Overall, recombination is a dynamic pathway with multiple metastable and reversible intermediates designed to achieve DNA repair with high fidelity.
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