期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 293, 期 27, 页码 10536-10546出版社
ELSEVIER
DOI: 10.1074/jbc.TM117.000375
关键词
genomic instability; DNA damage; DNA polymerase; DNA endonuclease; chromosomes; deletions; DNA ligation; microhomology; single-strand annealing; translocation; double-strand break; alternative end-joining pathway
资金
- National Institutes of Health [CA118100]
Alternative end-joining (a-EJ) pathways, which repair DNA double-strand breaks (DSBs), are initiated by end resection that generates 3 single strands. This reaction is shared, at least in part, with homologous recombination but distinguishes a-EJ from the major nonhomologous end-joining pathway. Although the a-EJ pathways make only a minor and poorly understood contribution to DSB repair in nonmalignant cells, there is growing interest in these pathways, as they generate genomic rearrangements that are hallmarks of cancer cells. Here, we review and discuss the current understanding of the mechanisms and regulation of a-EJ pathways, the role of a-EJ in human disease, and the potential utility of a-EJ as a therapeutic target in cancer.
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