期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 293, 期 14, 页码 5053-5061出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.TM117.000368
关键词
metabolic engineering; synthetic biology; polysaccharide; biomaterials; secretion
资金
- National Institutes of Health from NIGMS [P50 GM098792]
- National Science Foundation [MCB-1517913]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P50GM098792] Funding Source: NIH RePORTER
Polysaccharide-based biopolymers have many material properties relevant to industrial and medical uses, including as drug delivery agents, wound-healing adhesives, and food additives and stabilizers. Traditionally, polysaccharides are obtained from natural sources. Microbial synthesis offers an attractive alternative for sustainable production of tailored biopolymers. Here, we review synthetic biology strategies for select green biopolymers: cellulose, alginate, chitin, chitosan, and hyaluronan. Microbial production pathways, opportunities for pathway yield improvements, and advances in microbial engineering of biopolymers in various hosts are discussed. Taken together, microbial engineering has expanded the repertoire of green biological chemistry by increasing the diversity of biobased materials.
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