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Andres M. Lebensohn et al.
ELIFE (2018)
Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins
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BLOOD (2018)
LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway
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JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal
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Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types
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Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3
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Crystal Structure of LGR4-Rspo1 Complex INSIGHTS INTO THE DIVERGENT MECHANISMS OF LIGAND RECOGNITION BY LEUCINE-RICH REPEAT G-PROTEIN-COUPLED RECEPTORS (LGRs)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness
X. Gong et al.
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Engineering High-Potency R-spondin Adult Stem Cell Growth Factors
Margaret L. Warner et al.
MOLECULAR PHARMACOLOGY (2015)
Improved vectors and genome-wide libraries for CRISPR screening
Neville E. Sanjana et al.
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RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling
Kendra S. Carmon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Reconstitution of R-Spondin:LGR4:ZNRF3 Adult Stem Cell Growth Factor Signaling Complexes with Recombinant Proteins Produced in Escherichia coli
Heather E. Moad et al.
BIOCHEMISTRY (2013)
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin
Yang Xie et al.
EMBO REPORTS (2013)
The structural basis of R-spondin recognition by LGR5 and RNF43
Po-Han Chen et al.
GENES & DEVELOPMENT (2013)
Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network
Joshua C. Snyder et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Analysis of LGR4 Receptor Distribution in Human and Mouse Tissues
Jing Yi et al.
PLOS ONE (2013)
Crystal Structures of Lgr4 and Its Complex with R-Spondin1
Kai Xu et al.
STRUCTURE (2013)
Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin
Matthias Zebisch et al.
NATURE COMMUNICATIONS (2013)
Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5
Weng Chuan Peng et al.
CELL REPORTS (2013)
LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt/β-Catenin Signaling
Kendra S. Carmon et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Recurrent R-spondin fusions in colon cancer
Somasekar Seshagiri et al.
NATURE (2012)
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
Huai-Xiang Hao et al.
NATURE (2012)
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
Bon-Kyoung Koo et al.
NATURE (2012)
R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5
Heinz Ruffner et al.
PLOS ONE (2012)
Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis
Bisei Ohkawara et al.
DEVELOPMENTAL CELL (2011)
LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling
Andrei Glinka et al.
EMBO REPORTS (2011)
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
Wim de Lau et al.
NATURE (2011)
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling
Kendra S. Carmon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells
Laurens G. Van der Flier et al.
GASTROENTEROLOGY (2009)
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Toshiro Sato et al.
NATURE (2009)
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development
Olga Kazanskaya et al.
DEVELOPMENT (2008)
R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
Sheila M. Bell et al.
DEVELOPMENT (2008)
R-Spondin family members regulate the Wnt pathway by a common mechanism
Kyung-Ah Kim et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development
Motoko Aoki et al.
DEVELOPMENT GROWTH & DIFFERENTIATION (2008)
R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and β-catenin signaling
Qiou Wei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
R-spondin3 is required for mouse placental development
Motoko Aoki et al.
DEVELOPMENTAL BIOLOGY (2007)
Mutations in the gene encoding the Wnt-signaling component R-spondin 4 (RSPO4) cause autosomal recessive anonychia
C. Bergmann et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2006)
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia
Diana C. Blaydon et al.
NATURE GENETICS (2006)
R-spondin1 is essential in sex determination, skin differentiation and malignancy
Pietro Parma et al.
NATURE GENETICS (2006)
Mouse cristin/R-spondin family proteins are novel ligands for the frizzled 8 and LRP6 receptors and activate β-catenin-dependent gene expression
JS Nam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Vascular development in the retina and inner ear: Control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair
Q Xu et al.
CELL (2004)
R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants
T Kamata et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2004)
R-spondin2 is a secreted activator of Wnt/β-catenin signaling and is required for Xenopus myogenesis
O Kazanskaya et al.
DEVELOPMENTAL CELL (2004)
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