期刊
JOURNAL OF BIOCHEMISTRY
卷 164, 期 4, 页码 265-275出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvy063
关键词
partial EMT/MET; epithelial polarity; stem cell niche; metastable; malignancy
资金
- Kumamoto University
- Takeda Science Foundation
- Japan Society for Promotion of Science Kakenhi
Epithelial-mesenchymal transition (EMT) is a morphogenetic process of cells that adopt an epithelial organization in their developmental ontogeny or homeostatic maintenance. Abnormalities in EMT regulation result in many malignant tumours in the human body. Tumours associated with the haematopoietic system, however, are traditionally not considered to involve EMT and haematopoietic stem cells (HSCs) are generally not associated with epithelial characteristics. In this review, we discuss the ontogeny and homeostasis of adult HSCs in the context of EMT intermediate states. We provide evidence that cell polarity regulation is critical for both HSC formation from embryonic dorsal aorta and HSC self-renewal and differentiation in adult bone marrow. HSC polarity is controlled by the same set of surface and transcriptional regulators as those described in canonical EMT processes. With an emphasis on partial EMT, we propose that the concept of EMT can be similarly applied in the study of HSC generation, maintenance and pathogenesis.
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