期刊
JOURNAL OF BIOCHEMISTRY
卷 164, 期 2, 页码 77-85出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvy050
关键词
CCL8; CD169; intestinal inflammation; macrophage; tolerance
资金
- Japan Science and Technology Agency, PRESTO
- Japan Society for the Promotion of Science (JSPS) [26460401, 26293089]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan [26110006]
- MEXT
- Daiichi-Sankyo Foundation
- Uehara Memorial Foundation
- Takeda Science Foundation
- Naito Foundation
- Grants-in-Aid for Scientific Research [26110006, 26293089] Funding Source: KAKEN
Tissue macrophages comprise heterogeneous subsets that differ in localization, phenotype and ontogeny. They acquire tissue-specific phenotype in order to maintain normal tissue physiology. This review summarizes the current knowledge about the functions of CD169-positive macrophage subset residing in the lymphoid organs and intestinal tract. Strategically positioned at the interface between tissue and circulating fluid, CD169 + macrophages in the lymphoid organs capture blood-and lymph-borne particulate materials. Antigen information relayed by CD169 + macrophages to neighbouring immune cells is important for enhancement of antimicrobial and antitumour immunity as well as induction of tolerance. In the intestinal tract, CD169 + macrophages localize distantly from epithelial border. Following mucosal injury, they exacerbate inflammation by producing CCL8 that recruits inflammatory monocytes. As such, a better understanding of CD169 + macrophage phenotypes may enable the design of tissue-specific therapies for both immunological and non-immunological diseases.
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