期刊
JOURNAL OF AUTOIMMUNITY
卷 93, 期 -, 页码 104-113出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2018.07.003
关键词
Allergic asthma; Commensal bacteria; NLRP3/IL-1 beta signaling; Post-weaning mice
类别
资金
- National Natural Science Foundation of China [81788101, 91542000, 31400783]
Perturbation of commensal bacteria by antibiotic exposure aggravates ovalbumin (OVA)-induced allergic asthma in pre-weaning mice. However, the influence of dysbiosis of commensal bacteria on asthma development in post weaning mice is still limited. Here, we treated 3-week-old post-weaning mice with antibiotics to disrupt corn mensal bacteria and then established OVA-induced allergic asthma by peritoneal sensitization using OVA/alum and intranasal challenge with OVA. Contrary to the protective function in pre-weaning mice, commensal bacteria in post-weaning mice aggravated OVA-induced asthma. Commensal bacteria in post-weaning mice promoted OVA-induced allergic asthma through maintenance of NLRP3/IL-1 beta expression in peritoneal macrophages (pM phi), which promoted recruitment of inflammatory cells, especially inflammatory monocytes, into the peritoneal cavity after OVA/alum sensitization. Further study showed that metronidazole- and vancomycin-sensitive bacteria are involved in maintenance of NLRP3/IL-1 beta signal in pM phi. Our results suggest that certain species of commensal bacteria in post-weaning mice aggravate OVA-induced allergic asthma through NLRP3/IL-1 beta signal pathway.
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