期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 21, 期 10, 页码 961-969出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2018.1482880
关键词
Cyclohexanone derivatives; sesquiterpene; bioactivity; Nectria sp
资金
- National Natural Science Foundation of China [41606173, 81741152, 41306197]
- National High Technology Research and Development Program of China [SS2012AA09160703]
- Guangdong Innovative Development of Marine Economy Regional Demonstration Project [GD2012-D01-001]
Two new cyclohexanone derivatives, nectriatones A-B (1-2), and one new natural product, nectriatone C (3), together with three known phenolic sesquiterpene derivatives (4-6), were isolated from the culture of Nectria sp. B-13 obtained from high-latitude soil of the Arctic. The structures of all compounds were unambiguously elucidated by extensive spectroscopic analysis, as well as by comparison with the literature. These compounds were evaluated in cytotoxic and antibacterial activities. Compounds 1-6 showed cytotoxicities against SW1990, HCT-116, MCF-7, and K562 cells, with IC50 values in the range of 0.43 to 42.64 mu M. Only compound 4 exhibited antibacterial activity against Escherichisa coli, Bacillus subtilis, and Staphylococcus aureus (MIC 4.0, 2.0, and 4.0 mu g/ml, respectively).
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