期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 21, 期 7, 页码 619-626出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2018.1463996
关键词
Sargassum nigrifoloides; acylphloroglucinols; Alzheimer's diseases; CDK5; GSK3 beta
资金
- Natural Science Foundation of Shandong Province [ZR2018BB023, JQ201721]
- Young Taishan Scholars Program [tsqn20161037]
- Shandong Talents Team Cultivation Plan of University Preponderant Discipline [10027]
- Shandong Key Development Project [2016GSF201209]
- Natural Science Foundation of China [21672082]
Three new acylphloroglucinols (1-3) and four known biosynthetically related analogs (4-7) were isolated from the ethanol extract of a brown alga Sargassum nigrifoloides. Structures for 1-7 were characterized via detailed spectroscopic analyses especially 2D NMR data. Screening of these compounds in Alzheimer's diseases-related bioassays revealed moderate inhibitory activities against two therapeutically important kinases, CDK5 and GSK3 beta. A preliminary structure-activity relationship was also discussed. [GRAPHICS] .
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据