期刊
GENOME RESEARCH
卷 25, 期 10, 页码 1482-1490出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gr.190165.115
关键词
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资金
- National Institutes of Health (NIH) [R01 GM079205, R01 HD080224]
- European Research Council [340712]
- Israeli Science Foundation I-CORE on Chromatin and RNA in Gene Regulation
- European Research Council (ERC) [340712] Funding Source: European Research Council (ERC)
Eukaryotic genomes are packaged into an extensively folded state known as chromatin. Analysis of the structure of eukaryotic chromosomes has been revolutionized by development of a suite of genome-wide measurement technologies, collectively termed epigenomics. We review major advances in epigenomic analysis of eukaryotic genomes, covering aspects of genome folding at scales ranging from whole chromosome folding down to nucleotide-resolution assays that provide structural insights into protein-DNA interactions. We then briefly outline several challenges remaining and highlight new developments such as single-cell epigenomic assays that will help provide us with a high-resolution structural understanding of eukaryotic genomes.
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