期刊
GENOME BIOLOGY AND EVOLUTION
卷 7, 期 4, 页码 1039-1052出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evv054
关键词
dosage compensation; RNA stability; sex chromosomes; RNA half-life; ribosome density
资金
- JC Kempe Foundation
- Swedish Research Council [621-2012-2165]
- Swedish Cancer Foundation [CAN 2011/382]
Mammalian sex chromosomes evolved from the degeneration of one homolog of a pair of ancestral autosomes, the proto-Y. This resulted in a gene dose imbalance that is believed to be restored (partially or fully) through upregulation of gene expression from the single active X-chromosome in both sexes by a dosage compensatory mechanism. We analyzed multiple genome-wide RNA stability data sets and found significantly longer average half-lives for X-chromosome transcripts than for autosomal transcripts in various human cell lines, both male and female, and in mice. Analysis of ribosome profiling data shows that ribosome density is higher on X-chromosome transcripts than on autosomal transcripts in both humans and mice, suggesting that the higher stability is causally linked to a higher translation rate. Our results and observations are in accordance with a dosage compensatory upregulation of expressed X-linked genes. We therefore propose that differential mRNA stability and translation rates of the autosomes and sex chromosomes contribute to an evolutionarily conserved dosage compensation mechanism in mammals.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据