期刊
GENOME BIOLOGY AND EVOLUTION
卷 7, 期 8, 页码 2310-2320出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evv143
关键词
16S rRNA genes; intragenomic heterogeneity; horizontal gene transfer; accumulation of substitutions
资金
- Sanya Institute of Deep Sea Science and Engineering, the Chinese Academy of Sciences (SIDSSE, CAS) [SIDSSE-201206, XDB06010102]
- China Ocean Mineral Resource RD Association [COMRRDA12SC01]
- National Basic Research Program of China (973 Program) [2012CB417304]
- HKSAR government [661611]
Horizontal gene transfer (HGT) of operational genes has been widely reported in prokaryotic organisms. However, informational genes such as those involved in transcription and translation processes are very difficult to be horizontally transferred, as described by Woese's complexity hypothesis. Here, we analyzed all of the completed prokaryotic genome sequences (2,143 genomes) in the NCBI (National Center for Biotechnology Information) database, scanned for genomes with high intragenomic heterogeneity of 16S rRNA gene copies, and explored potential HGT events of ribosomal RNA genes based on the phylogeny, genomic organization, and secondary structures of the ribosomal RNA genes. Our results revealed 28 genomes with relatively high intragenomic heterogeneity of multiple 16S rRNA gene copies (lowest pairwise identity <98.0%), and further analysis revealed HGT events and potential donors of the heterogeneous copies (such as HGT from Chlamydia suis to Chlamydia trachomatis) and mutation events of some heterogeneous copies (such as Streptococcus suis JS14). Interestingly, HGT of the 16S rRNA gene only occurred at intragenus or intraspecies levels, which is quite different from the HGT of operational genes. Our results improve our understanding regarding the exchange of informational genes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据