期刊
WORLD JOURNAL OF CLINICAL ONCOLOGY
卷 5, 期 4, 页码 667-676出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.5306/wjco.v5.i4.667
关键词
Acetylcholine receptor; Pathway; CHRNA; Nicotine; Pulmonary carcinoma
类别
资金
- Youth Foundation of Shanghai Municipal Public Health Bureau [20124Y114]
- Shanghai Chest Hospital 1050 Talents Project, China
- Project of Shanghai Chest Hospital [YZ13-16]
Genome-wide association studies revealed that allelic variation in the alpha 5-alpha 3-beta 4 nicotine acetylcholine receptor (nAChR) cluster on chromosome 15q24-15q25.1 was associated with lung cancer risk. nAChRs are membrane ligand-gated cation channels whose activation is triggered by the binding of the endogenous neurotransmitter acetylcholine (ACh) or other biologic compounds including nicotine. nAChRs have been found on lung cancer cells, underscoring the idea that the non-neuronal nAChR pathway has important implications for lung cancer. Several studies focusing on the treatment with nAChR antagonists with improved selectivity might trigger novel strategies for the intervention and prevention of lung cancer. Here we review the genetic risk factors for lung cancer in the nAChR gene cluster, the roles of nicotine receptors, and the molecular mechanisms of acetylcholine receptor pathways to lead to more opportunities for intervention and prevention of lung cancer. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据