期刊
JOURNAL OF APPLIED PHYSICS
卷 123, 期 18, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.5026749
关键词
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资金
- National Natural Science Foundation of China [81627807, 81571725, 61372046, 61401264, 11571012, 61640418, 61701403]
- Fok Ying-Tong Education Foundation of China [161104]
- Research Fund for Young Star of Science and Technology in Shaanxi Province [2017SR5029]
- Fundamental Research Funds for the Central Universities [JB171202]
Cerenkov luminescence imaging (CLI) is an imaging method that uses an optical imaging scheme to probe a radioactive tracer. Application of CLI with clinically approved radioactive tracers has opened an opportunity for translating optical imaging from preclinical to clinical applications. Such translation was further improved by developing an endoscopic CLI system. However, two-dimensional endoscopic imaging cannot identify accurate depth and obtain quantitative information. Here, we present an imaging scheme to retrieve the depth and quantitative information from endoscopic Cerenkov luminescence tomography, which can also be applied for endoscopic radio-luminescence tomography. In the scheme, we first constructed a physical model for image collection, and then a mathematical model for characterizing the luminescent light propagation from tracer to the endoscopic detector. The mathematical model is a hybrid light transport model combined with the 3rd order simplified spherical harmonics approximation, diffusion, and radiosity equations to warrant accuracy and speed. The mathematical model integrates finite element discretization, regularization, and primal-dual interior-point optimization to retrieve the depth and the quantitative information of the tracer. A heterogeneous-geometry-based numerical simulation was used to explore the feasibility of the unified scheme, which demonstrated that it can provide a satisfactory balance between imaging accuracy and computational burden. Published by AIP Publishing.
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