期刊
JOURNAL OF ANATOMY
卷 233, 期 2, 页码 266-273出版社
WILEY
DOI: 10.1111/joa.12824
关键词
lactation; mammary gland; mastitis; milk duct; pregnancy; rabbit; sinus; tumour
资金
- British Veterinary Association Animal Welfare Foundation Norman Hayward Fund [NHF_2016_03_KH]
- Medical Research Council [MR/J001023/1]
- Ethics and Welfare Committee of the Department of Veterinary Medicine, University of Cambridge [CR240]
- MRC [MR/J001023/1] Funding Source: UKRI
Sinus-like dilatations of the mammary duct are recognisable in the mammary gland of pregnant and lactating wild European rabbits. These dilatations exhibit a bilaminar epithelial lining, with luminal epithelial cells expressing basal and lateral E-cadherin. Occasional binucleated mammary epithelial cells are present in the luminal layer. Underlying the luminal epithelial cells is a basal layer of cytokeratin 14-positive cells, supported by a thin layer of fibrous tissue. Multi-segmental epithelial proliferation, as indicated by Ki67 expression, is apparent in the luminal epithelial cells, suggesting a capacity for division during pregnancy and lactation. CD3-positive T lymphocytes are present both intraepithelially, suggesting exocytosis, and in foci subjacent to the ductular epithelium. We consider that sinus-like dilatations of the mammary duct may have the potential to give rise to a subset of the mammary gland neoplasms classified as ductal in origin. Milk accumulation in these sinus-like dilatations is likely to provide a niche for bacterial replication in cases of mastitis in rabbits. These structures are an important component of the innate immune system of the mammary gland, both as a physical barrier and as an interface between the milk and mammary immune cells.
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