期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 45, 页码 25014-25023出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b06938
关键词
photothermal therapy; magnetic resonance imaging; chemotherapy; multimodal therapy; drug delivery; mesoporous silica nanoparticles; gadolinium(III)-chelated silica nanospheres
资金
- MOST 973 program [2012CB934000]
- International Science and Technology Cooperation Program of China [2013DFG32340, 2014DFG52500]
- NSFC [21320102003, 11205166]
- National Science Fund for Distinguished Young Scholars [11425520]
The combination of therapy and diagnosis has been emerging as a promising strategy for cancer treatment. To realize chemotherapy, photothermal therapy, and magnetic resonance imaging (MRI) in one system, we have synthesized a new magnetic nanoparticle (Gd@SiO2-DOX/ICG-PDC) integrating doxorubicin (DOX), indocyanine green (ICG), and gadolinium(III)-chelated silica nanospheres (Gd@SiO2) with a poly(diallyldimethylammonium chloride) (PDC) coating. PDC coating serves as a polymer layer to protect from quick release of drugs from the nanocarriers and increase cellular uptake. The DOX release from Gd@SiO2-DOX/ICG-PDC depends on pH and temperature. The process will be accelerated in the acidic condition than in a neutral pH 7.4. Meanwhile, upon laser irradiation, the photothermal effects promote DOX release and improve the therapeutic efficacy compared to either DOX-loaded Gd@SiO2 or ICG-loaded Gd@SiO2. Moreover, MRI results show that the Gd@SiO2-PDC nanoparticles are safe T-1-type MRI contrast agents for imaging. The Gd@SiO2-PDC nanoparticles loaded with DOX and ICG can thus act as a promising theranostic platform for multimodal cancer treatment.
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