期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 63, 期 4, 页码 1223-1234出版社
IOS PRESS
DOI: 10.3233/JAD-180098
关键词
Alzheimer's disease; astrocyte; blood-brain barrier; endothelial cell; pericyte
资金
- Chongqing Health and Family Planning Scientific Research Project [ZY201702042]
- Nature Science Foundation of Chongqing General Hospital
The blood-brain barrier (BBB) is involved in the pathogenesis of Alzheimer's disease (AD). BBB is a highly selective semipermeable structural and chemical barrier which ensures a stable internal environment of the brain and prevents foreign objects invading the brain tissue. BBB dysfunction induces the failure of A beta transport from brain to the peripheral circulation across the BBB. Especially, decreased levels of LRP-1 (low density lipoprotein receptor-related protein 1) and increased levels of RAGE (receptor for advanced glycation endproducts) at the BBB can cause the failure of A beta transport. The pathogenesis of AD is related to the BBB structural components, including pericytes, astrocytes, vascular endothelial cells, and tight junctions. BBB dysfunction will trigger neuroinflammation and oxidative stress, then enhance the activity of beta-secretase and gamma-secretase, and finally promote A beta generation. A progressive accumulation of A beta in brain and BBB dysfunction may become a feedback loop that gives rise to cognitive impairment and the onset of dementia. The correlation between BBB dysfunction and tau pathology has been well-reported. Therefore, regulating BBB function may be a new therapeutic target for treating AD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据