期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 62, 期 3, 页码 1381-1390出版社
IOS PRESS
DOI: 10.3233/JAD-170829
关键词
Ceramides; dementia; diabetes; insulin resistance; neuroinflammation; nitrosamines; obesity; streptozotocin; Type 3 diabetes; vascular steatohepatitis
资金
- NIAAA NIH HHS [R56 AA011431, R01 AA011431, R37 AA011431] Funding Source: Medline
- NIA NIH HHS [R44 AG049510] Funding Source: Medline
The Journal of Alzheimer's Disease (JAD), founded in 1998, played a pivotal role in broadening the field of research on Alzheimer's disease (AD) by publishing a diverse range of clinical, pathological, molecular, biochemical, epidemiological, experimental, and review articles from its birth. This article recounts my own journey as an author who contributed articles to JAD over the 20 years of the journal's existence. In retrospect, it seems remarkable that a considerable body of work that originated from our group marks a trail that began with studies of vascular, stress, and mitochondrial factors in AD pathogenesis, exploded into the concept of 'Type 3 Diabetes', and continued with the characterization of how environmental, exposure, and lifestyle factors promote neurodegeneration and which therapeutic strategies could reverse the neurodegeneration cascade.
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