期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 61, 期 4, 页码 1589-1598出版社
IOS PRESS
DOI: 10.3233/JAD-170742
关键词
Alzheimer's disease; amyloid-beta; dietary fiber; dietary protein; PiB PET
资金
- CSIRO Flagship Collaboration Fund
- Science and Industry Endowment Fund (SIEF)
- Edith Cowan University (ECU)
- Florey Institute of Neuroscience and Mental Health
- Alzheimer's Australia (AA)
- National Ageing Research Institute (NARI)
- Austin Health
- CogState Ltd.
- Hollywood Private Hospital
- Sir Charles Gairdner Hospital
- National Health and Medical Research Council (NHMRC)
- Dementia Collaborative Research Centres program (DCRC2)
- Cooperative Research Centre (CRC) for Mental Health through the CRC Program (an Australian Government Initiative) [20100104]
- McCusker Alzheimer's Research Foundation
Accumulating evidence suggests a diet high in protein and fiber may confer some protection against Alzheimer's disease (AD). However, no human studies to-date have assessed the relationship between protein and fiber intake, and plasma and brain amyloid-beta (A beta). Consequently, this cross-sectional study, investigated the association of self-reported dietary intakes of protein and fiber, with plasma and brain A beta burden (n = 541, and n = 162 respectively), in a well-characterized cohort of cognitively normal older adults, drawn from the larger Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. We observed 12.59 and 8.43 higher odds of 'high' brain A beta burden (PiB PET SUVR >= 1.5) if protein intake fell in the lowest and middle tertile, respectively, compared to the highest tertile (p = 0.008; p = 0.013). Thus, in this cohort, the more protein consumed, the less likelihood of 'high' A beta burden in the brain. No other significant associations were observed. The results of this study highlight the potentially protective impact of high dietary protein intake on brain A beta burden in older adults, before objective memory decline is apparent. While longitudinal validation is required, these findings may assist in the development of dietary approaches aimed at preventing or delaying AD onset.
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