期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 64, 期 1, 页码 269-279出版社
IOS PRESS
DOI: 10.3233/JAD-171059
关键词
Activities of daily living; Alzheimer's disease; cognition; dementia; follow-up study; functional ability
资金
- Kuopio University Hospital [1V255/5772728]
- Paivikki and Sakari Sohlberg Foundation
Background: Impaired cognition and activities of daily living (ADL) are core symptoms of Alzheimer's disease (AD), but their relationship is unclear. Objectives: To explore relationships between cognitive domains and functional ability during 5-year follow-up in persons with AD. Methods: We analyzed ALSOVA study data from 236 individuals with very mild or mild AD at baseline. The CERAD Neuropsychological Battery (CERAD-NB) was used as a cognitive measure and Alzheimer's Disease Cooperative Study ADL (ADCS-ADL) as a functional measure, analyzing the IADL and BADLsub- scores separately. Annual regression models and linear mixed-effect models (LMMs) covering a 5-year follow-up period were used. Results: Annually, the CERAD-NB total and especially Verbal Fluency, Clock Drawing, and Constructional Praxis were associated with the total ADCS-ADL and IADL scores increasingly yet modestly, and to a lesser extent the BADL score. In the LMMs, the same measures and MMSE were associated with ADL. Conclusion: Measures of executive function and visuoconstructive skills appear to be associated with caregiver-interview based ADL measure during the progression of AD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据